Methanol → HCID 66642764, compound

HRID 869234Notes

Reaction equation

HRID 869234 reaction equation
Cl[C:2]1[C:7]([C:8]([NH2:10])=[O:9])=[C:6]([NH:11][C:12]2[CH:13]=[N:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[N:5]=[C:4]([S:19][CH3:20])[N:3]=1.[CH3:21][OH:22].C[O-].[Na+]>O>[CH3:21][O:22][C:2]1[C:7]([C:8]([NH2:10])=[O:9])=[C:6]([NH:11][C:12]2[CH:13]=[N:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[N:5]=[C:4]([S:19][CH3:20])[N:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 86662044HCID 86662044, compound

Product 1

HCID 66642764HCID 66642764, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 4-chloro-6-[(6-methylpyridin-3-yl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxamide (Preparation Example 303) (51 mg) and methanol (1 mL), sodium methoxide (11 mg) was added under ice cooling and stirred overnight at room temperature. Water was added to the reaction liquid, and the solid was collected by filtration to give 4-methoxy-6-[(6-methylpyridin-3-yl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxamide (41 mg).

Workup

  1. additionwas added under ice cooling
  2. filtrationthe solid was collected by filtration

Sources & evidence

ORD record
ord-68479a60ca3b4d169b95deac50003ea8
Source dataset
uspto-grants-2015_03
Patent number
US08969336B2

Reaction notes

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