HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 66642764, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 86662044 | HCID 86662044 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 66642764 | HCID 66642764 | — |
Reaction Steps
To a mixture of 4-chloro-6-[(6-methylpyridin-3-yl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxamide (Preparation Example 303) (51 mg) and methanol (1 mL), sodium methoxide (11 mg) was added under ice cooling and stirred overnight at room temperature. Water was added to the reaction liquid, and the solid was collected by filtration to give 4-methoxy-6-[(6-methylpyridin-3-yl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxamide (41 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969336B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-68479a60ca3b4d169b95deac50003ea8 |
| Source note | uspto-grants-2015_03 |