反应详情

A suspension of 2-[2-(3-chloro-phenylethynyl)-pyrimidin-4-yl]-1-methyl-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (0.018 g, 0.05 mmol) in 4M HCl in dioxane (3.0 ml) was stirred at room temperature for 2 h. The solvent was removed under vacuum and the crude was purified by column chromatography over silica gel, using DCM/MeOH (9.8:0.2) as eluent, affording 2-[2-(3-Chloro-phenylethynyl)-pyrimidin-4-yl]-1-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one as a yellow solid (0.007 g, 0.02 mmol, 50%).

1. customThe solvent was removed under vacuum
2. customthe crude was purified by column chromatography over silica gel