HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl (3-{[[4-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl](2-morpholin-4-ylethyl)amino]methyl}phenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Morpholinoethylamine | HCID 408285 | — |
| Reactant | (3-Bromomethyl-phenyl)-acetic acid methyl ester | HCID 10014651 | — |
| Reactant | 9-(4-Bromobutyl)-2-butoxy-8-methoxyadenine | HCID 23158511 | — |
| Product | Methyl (3-{[[4-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl](2-morpholin-4-ylethyl)amino]methyl}phenyl)acetate | HCID 11613901 | — |
Reaction Steps
Using the compound obtained in Example 2-13 step (i) (500 mg), (2-morpholin-4-ylethyl)amine (1 ml), potassium carbonate (206 mg) and methyl [3-(bromomethyl)phenyl]acetate (180 mg), the same manner to Example 2-29 was conducted to give the titled compound as a white solid. Yield: 100 mg (13%); mp 189-190° C., MS APCI+ve 570 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969362B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-30ff974719d546659c387f893bc5371b |
| Source note | uspto-grants-2015_03 |