HRID869357

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID408285

2-Morpholinoethylamine

C6H14N2O

HCID10014651

(3-Bromomethyl-phenyl)-acetic acid methyl ester

C10H11BrO2

反应SMILES：CCCCOc1nc(N)c2nc(OC)n(CCCCBr)c2n1

HCID23158511

未命名化合物

PRODUCTS

产物

反应SMILES：CCCCOc1nc(N)c2[nH]c(=O)n(CCCCN(CCN3CCOCC3)Cc3cccc(CC(=O)OC)c3)c2n1

HCID11613901

未命名化合物

PROCEDURE

实验过程

Using the compound obtained in Example 2-13 step (i) (500 mg), (2-morpholin-4-ylethyl)amine (1 ml), potassium carbonate (206 mg) and methyl [3-(bromomethyl)phenyl]acetate (180 mg), the same manner to Example 2-29 was conducted to give the titled compound as a white solid. Yield: 100 mg (13%); mp 189-190° C., MS APCI+ve 570 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-30ff974719d546659c387f893bc5371b
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08969362B2
来源说明: uspto-grants-2015_03

反应SMILES

Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:14]([O:15]C)=[N:13][C:12]2[C:7]1=[N:8][C:9]([O:18][CH2:19][CH2:20][CH2:21][CH3:22])=[N:10][C:11]=2[NH2:17].[N:23]1([CH2:29][CH2:30][NH2:31])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:39][C:40]1[CH:41]=[C:42]([CH2:46][C:47]([O:49][CH3:50])=[O:48])[CH:43]=[CH:44][CH:45]=1>>[NH2:17][C:11]1[N:10]=[C:9]([O:18][CH2:19][CH2:20][CH2:21][CH3:22])[N:8]=[C:7]2[C:12]=1[NH:13][C:14](=[O:15])[N:6]2[CH2:5][CH2:4][CH2:3][CH2:2][N:31]([CH2:39][C:40]1[CH:41]=[C:42]([CH2:46][C:47]([O:49][CH3:50])=[O:48])[CH:43]=[CH:44][CH:45]=1)[CH2:30][CH2:29][N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1