Lithium Hydroxide → HCID 11589700, compound

HRID 869363Notes

Reaction equation

HRID 869363 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:31])[N:6]2[CH2:16][CH2:17][CH2:18][NH:19][C:20]1[CH:21]=[C:22]([CH2:26][C:27]([O:29]C)=[O:28])[CH:23]=[CH:24][CH:25]=1.[OH-].[Li+]>CO.O>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:31])[N:6]2[CH2:16][CH2:17][CH2:18][NH:19][C:20]1[CH:21]=[C:22]([CH2:26][C:27]([OH:29])=[O:28])[CH:23]=[CH:24][CH:25]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 11539197HCID 11539197, compound

Product 1

HCID 11589700HCID 11589700, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

The compound obtained in Example 2-42 (70 mg) was dissolved in methanol (5 ml) and a lithium hydroxide solution (45 mg) in water (5 ml) was added thereto. The same manner to Example 2-12 was conducted to give the titled compound as a colorless solid. Yield: 14 mg (21%); mp 247° C., MS APCI-ve 413 (M−H).

Sources & evidence

ORD record
ord-7cebd42b0a774af2a80909bc6103e37e
Source dataset
uspto-grants-2015_03
Patent number
US08969362B2

Reaction notes

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