HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 869364Generated: October 31, 2026
Ethanolamine → 2-{[2-(6-Amino-2-butoxy-8-methoxy-9H-purin-yl)ethyl]amino}ethanol
https://huagongshe.com/reaction/869364
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 9-(2-Bromoethyl)-2-butoxy-8-methoxy-9H-purin-6-amine | HCID 58942893 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-{[2-(6-Amino-2-butoxy-8-methoxy-9H-purin-yl)ethyl]amino}ethanol | HCID 58551929 | — |
Reaction Steps
To the compound obtained by Example 2-39 step (i) (300 mg) in acetonitrile (5 ml) was added 2-aminoethanol (265 mg) and heated at 70° C. for 24 hours. The reaction mixture was purified by column chromatography (ethyl acetate:7N ammonia-methanol 95:5) to give the titled compound. Yield: 295 mg (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08969362B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-0eb8db709996431dad2ef4999b0e37d5 |
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| Source note | uspto-grants-2015_03 |
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