Hydrochloric Acid → HCID 11501933, compound

HRID 869365Notes

Reaction equation

HRID 869365 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([NH:10][C:11](=[O:28])[N:12]2[CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([O:26]C)=[O:25])[CH:19]=2)=[C:8]([NH2:29])[N:7]=1)[CH2:2][CH2:3][CH3:4].CO.[OH-].[K+].Cl>O>[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([NH:10][C:11](=[O:28])[N:12]2[CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([OH:26])=[O:25])[CH:19]=2)=[C:8]([NH2:29])[N:7]=1)[CH2:2][CH2:3][CH3:4]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14797Potassium HydroxideHCID 11395502HCID 11395502, compound

Product 1

HCID 11501933HCID 11501933, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
85 °C

Procedure

To 2-butoxy-8-oxo-9-[2-(3-methoxycarbonylphenoxy)ethyl]adenine (50 mg, 0.12 mmol) obtained in Example 1 were added methanol (2.5 ml) and 2.5N potassium hydroxide (5 m), and the mixture was stirred at 85° C. for 4.5 hours. After cooling, water was added and the resultant was made to pH 5 by concentrated hydrochloric acid. The precipitated crystal was collected by filtration to give 49 mg (0.12 mmol) of the titled compound as a white solid. Yield: 100%.

Workup

  1. temperatureAfter cooling
  2. filtrationThe precipitated crystal was collected by filtration

Sources & evidence

ORD record
ord-d90a47d4d8c84c8185130f89074ff19b
Source dataset
uspto-grants-2015_03
Patent number
US08969362B2

Reaction notes

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