Sodium Hydroxide → HCID 23158505, compound

HRID 869369Notes

Reaction equation

HRID 869369 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([O:11][C:12]1[N:20]=[C:19]2[C:15]([N:16]=[CH:17][N:18]2[CH2:21][CH2:22][O:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[C:30](OC)=[O:31])=[C:14]([NH2:34])[N:13]=1)[CH2:8][CH2:9][CH3:10].[OH-].[Na+]>C1COCC1>[CH2:7]([O:11][C:12]1[N:20]=[C:19]2[C:15]([N:16]=[CH:17][N:18]2[CH2:21][CH2:22][O:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH2:30][OH:31])=[C:14]([NH2:34])[N:13]=1)[CH2:8][CH2:9][CH3:10]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 23158493HCID 23158493, compound

Product 1

HCID 23158505HCID 23158505, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a suspension of lithium aluminum hydride (74 mg, 1.9 mmol) in THF (10 ml) was added a solution of 2-butoxy-9-[2-(2-methoxycarbonylphenoxy)ethyl]adenine (500 mg, 1.4 mmol) obtained by Reference Example 5 in THF (2 ml) under ice-cooling, and the mixture was stirred at room temperature for 1 hour. 1N Aqueous sodium hydroxide solution was added thereto, followed by filtration through celite pad, and the filtrate was concentrated under reduced pressure to give 500 mg (1.4 mmol) of the titled compound as a white solid. Yield: 99%.

Workup

  1. temperaturecooling
  2. filtrationfollowed by filtration through celite pad
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-9ca12ad4667448d485d5125d5cadea20
Source dataset
uspto-grants-2015_03
Patent number
US08969362B2

Reaction notes

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