Phosphorus oxychloride → HCID 58192232, compound

HRID 869373Notes

Reaction equation

HRID 869373 reaction equation
[C:1]1([C:7]2[N:12]=[C:11]3[C:13]4[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=4[O:15][C:10]3=[C:9](O)[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:9]1[CH:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:12]=[C:11]2[C:13]3[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=3[O:15][C:10]=12

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178515548HCID 178515548, compound

Product 1

HCID 58192232HCID 58192232, compound

Conditions

Temperature
110 °C

Procedure

1D (53.6 mmol) was added to POCl3 (90 mL), heated to dissolve and stirred at 110° C. for 2.5 hours. TLC showed the reaction completed. POCl3 was evaporated under reduced pressure. The residue was cooled and poured into ice-water under stirring. The solids were collected by filtration and dried to give the desired product M1 (11.5 g).

Workup

  1. temperatureheated
  2. dissolutionto dissolve
  3. customPOCl3 was evaporated under reduced pressure
  4. temperatureThe residue was cooled
  5. additionpoured into ice-water
  6. stirringunder stirring
  7. filtrationThe solids were collected by filtration
  8. customdried

Sources & evidence

ORD record
ord-f6e8b3b3e5544fb6b385d522b14789c2
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

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