2-Hydroxybenzonitrile → 1-(3-Amino-4-chlorobenzo[B]thiophen-2-YL)ethanone

HRID 869375Notes

Reaction equation

[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([SH:10])[C:3]=1[C:4]#[N:5].[OH:11][C:12]1[CH:19]=CC=C[C:13]=1C#N>>[NH2:5][C:4]1[C:3]2[C:2]([Cl:1])=[CH:9][CH:8]=[CH:7][C:6]=2[S:10][C:13]=1[C:12](=[O:11])[CH3:19]

Participants

Reactant 2

HCID 119072-Hydroxybenzonitrile

HCID 212247652-Chloro-6-sulfanylbenzonitrile

Product 1

HCID 126146401-(3-Amino-4-chlorobenzo[B]thiophen-2-YL)ethanone

Procedure

The procedure was similar to step S1A, while the starting material was 2-chloro-6-mercapto-benzonitrile (2A) in stead of 2-hydroxy-benzonitrile.

Sources & evidence

ORD record: ord-df4e7cfff2e7493caad3d35683dfb269
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08969373B2

Reaction notes

Loading…