Water → HCID 86722240, compound

HRID 869391Notes

Reaction equation

HRID 869391 reaction equation
[NH2:1][C:2]1[C:6]2[C:7]([Cl:13])=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:14](=[O:25])[CH:15]=[CH:16][C:17]1[N:18]=[C:19]([CH:22]([CH3:24])[CH3:23])[S:20][CH:21]=1.O>CC(O)=O.OP(O)(O)=O>[Cl:13][C:7]1[C:6]2[C:2]3[NH:1][CH:16]([C:17]4[N:18]=[C:19]([CH:22]([CH3:23])[CH3:24])[S:20][CH:21]=4)[CH2:15][C:14](=[O:25])[C:3]=3[O:4][C:5]=2[CH:10]=[CH:9][C:8]=1[O:11][CH3:12]

Participants

5

Reactant 2

HCID 962WaterHCID 86722239HCID 86722239, compound

Product 1

HCID 86722240HCID 86722240, compoundYield 108.4%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 1004Phosphoric AcidSolvent

Procedure

10A (9.96 g, 26.43 mmol) was dissolved in AcOH (50 mL) and H3PO4 (50 mL). The solution was refluxed for 2 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was cooled to room temperature and poured into water (200 mL) The brown precipitates were collected by filtration and dried to give product 10B (10.8 g), which was used for the next step directly.

Workup

  1. temperatureThe solution was refluxed for 2 hours
  2. customthe reaction
  3. custombrown precipitates
  4. filtrationwere collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-be5b8a68658446a68a3c0d5d799e4af6
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

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