反应详情

11C (0.5 g, 2.5 mmol) was dissolved in THF (10 mL). To the solution at room temperature was added activated MnO2 (1.74 g, 20 mmol). The reaction mixture was refluxed overnight, then filtered. The filtrate was concentrated and dried to give a crude product 11D (0.25 g, 50% yield).

1. temperatureThe reaction mixture was refluxed overnight
2. filtrationfiltered
3. concentrationThe filtrate was concentrated
4. customdried