反应详情

11F (500 mg, 1.19 mmol) was dissolved in THF (tetrahydrofuran, 30 mL). To the solution was added activated MnO2 (600 mg, 6 eq, 6.9 mmol). The mixture was refluxed for 48 hours. After reaction completed, the mixture was cooled and filtered. The cake was washed well with THF and MeOH. The filtrate was concentrated and purified by column chromatography on silica gel to give 300 mg of pure product (11G).

1. temperatureThe mixture was refluxed for 48 hours
2. customAfter reaction
3. temperaturethe mixture was cooled
4. filtrationfiltered
5. washThe cake was washed well with THF and MeOH
6. concentrationThe filtrate was concentrated
7. custompurified by column chromatography on silica gel