Phosphorus oxychloride → HCID 86722246, compound

HRID 869401Notes

Reaction equation

HRID 869401 reaction equation
O[C:2]1[CH:7]=[C:6]([C:8]2[N:9]=[C:10]([NH:13][C:14](=[O:18])[CH:15]([CH3:17])[CH3:16])[S:11][CH:12]=2)[N:5]=[C:4]2[C:19]3[C:25]([Cl:26])=[C:24]([O:27][CH3:28])[CH:23]=[CH:22][C:20]=3[O:21][C:3]=12.O=P(Cl)(Cl)[Cl:31]>>[Cl:31][C:2]1[CH2:7][CH:6]([C:8]2[N:9]=[C:10]([NH:13][C:14](=[O:18])[CH:15]([CH3:17])[CH3:16])[S:11][CH:12]=2)[N:5]=[C:4]2[C:19]3[C:25]([Cl:26])=[C:24]([O:27][CH3:28])[CH:23]=[CH:22][C:20]=3[O:21][C:3]=12

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178488264HCID 178488264, compound

Product 1

HCID 86722246HCID 86722246, compound

Procedure

A mixture of 11G (300 mg, 0.72 mmol) in POCl3 (5 mL) was refluxed for 30 min. After reaction completed, POCl3 was evaporated under reduced pressure. The residue was poured into crushed ice and stirred for 10 min. The solids were collected by filtration and dried to give 161 mg of product (M11).

Workup

  1. temperaturewas refluxed for 30 min
  2. customAfter reaction
  3. customPOCl3 was evaporated under reduced pressure
  4. additionThe residue was poured
  5. custominto crushed ice
  6. filtrationThe solids were collected by filtration
  7. customdried

Sources & evidence

ORD record
ord-8b3fe11e906d4274b7f918cfdd4c63cd
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

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