1,4-Dioxane → HCID 178488260, compound

HRID 869408Notes

Reaction equation

HRID 869408 reaction equation
[Br:1][C:2]1[C:7]2[C:8]3[NH:9][CH:10]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH2:11][C:12](=[O:15])[C:13]=3[O:14][C:6]=2[CH:5]=[CH:4][C:3]=1[O:22][CH3:23].O1CCOCC1>O>[OH:15][C:12]1[CH:11]=[C:10]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:9]=[C:8]2[C:7]3[C:2]([Br:1])=[C:3]([O:22][CH3:23])[CH:4]=[CH:5][C:6]=3[O:14][C:13]=12

Participants

4

Reactant 2

HCID 312751,4-DioxaneHCID 86722254HCID 86722254, compound

Product 1

HCID 178488260HCID 178488260, compoundYield 91.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 13B (2.0 g, 0.0053 mol), FeCl3.6H2O (6 g) and 1,4-dioxane (20 mL) was heated to 110° C. and reacted overnight. After reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 13C (1.8 g, 90.4% yield).

Workup

  1. customreacted overnight
  2. customAfter reaction
  3. filtrationThe precipitated solids were collected by filtration

Sources & evidence

ORD record
ord-404d11d24fa74ec28337283a7a32ac72
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

Loading…