Tetrahydrofuran → HCID 86722257, compound

HRID 869411Notes

Reaction equation

HRID 869411 reaction equation
[Br:1][C:2]1[C:7]2[C:8]3N[CH:10]([C:16]4[S:20][C:19]([CH:21]([CH3:23])[CH3:22])=[N:18][CH:17]=4)[CH2:11][C:12](=[O:15])[C:13]=3[O:14][C:6]=2[CH:5]=[CH:4][C:3]=1[O:24][CH3:25].[CH2:26]1COCC1>O=[Mn]=O>[OH:15][C:12]1[C:13]2[O:14][C:6]3[CH:5]=[CH:4][C:3]([O:24][CH3:25])=[C:2]([Br:1])[C:7]=3[C:8]=2[CH:26]=[C:10]([C:16]2[S:20][C:19]([CH:21]([CH3:23])[CH3:22])=[N:18][CH:17]=2)[CH:11]=1

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 86722256HCID 86722256, compound

Product 1

HCID 86722257HCID 86722257, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 14801Manganese dioxideCatalyst

Conditions

Temperature
110 °C

Procedure

A mixture of 14B (1.1 g, 2.6 mmol), MnO2 (6 g) in THF (20 mL) was heated to 110° C. and reacted overnight, then filtered. The filtrate was concentrated to give 14C (0.8 g, 73% yield).

Workup

  1. customreacted overnight
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-194d0693e9bd465e99fcac510c240b56
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

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