Acetic Acid → HCID 86722259, compound

HRID 869413Notes

Reaction equation

HRID 869413 reaction equation
[NH2:1][C:2]1[C:6]2[C:7]([Br:13])=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:14](=[O:25])[CH:15]=[CH:16][C:17]1[N:18]=[C:19]([CH:22]([CH3:24])[CH3:23])[S:20][CH:21]=1.CC(O)=O.OP(O)(O)=O>O>[Br:13][C:7]1[C:6]2[C:2]3[NH:1][CH:16]([C:17]4[N:18]=[C:19]([CH:22]([CH3:23])[CH3:24])[S:20][CH:21]=4)[CH2:15][C:14](=[O:25])[C:3]=3[O:4][C:5]=2[CH:10]=[CH:9][C:8]=1[O:11][CH3:12]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1004Phosphoric AcidHCID 86722258HCID 86722258, compound

Product 1

HCID 86722259HCID 86722259, compoundYield 71.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 15A (2.8 g, 6.6 mmol), AcOH (10 mL) and H3PO4 (10 mL) was heated to 90° C. and reacted for 2 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 15B (2 g, 71.4% yield).

Workup

  1. customreacted for 2 hours
  2. customthe reaction
  3. filtrationThe precipitated solids were collected by filtration

Sources & evidence

ORD record
ord-af619ac7e3bc4702b566890ed67be1a0
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

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