HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 869414Generated: October 30, 2026
Water → 4-Hydroxyl-9-bromo-2-(2-isopropyl-thiazol-4-yl)-8-methoxy-benzofuro[3,2-b]pyridine
https://huagongshe.com/reaction/869414
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 86722259 | HCID 86722259 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Hydroxyl-9-bromo-2-(2-isopropyl-thiazol-4-yl)-8-methoxy-benzofuro[3,2-b]pyridine | HCID 178488261 | 60.9% |
Reaction Steps
A mixture of 15B (2.0 g, 4.7 mmol), FeCl3.6H2O (6 g) in 1,4-dioxane (20 mL) was heated to 110° C. and reacted overnight. TLC monitored the reaction. After the reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 15C (1.2 g, 60.2% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08969373B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-dcd467b0925649f9a1b065fa10fa19fd |
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| Source note | uspto-grants-2015_03 |
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