Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 21914786 | HCID 21914786 | — |
| Reactant | HCID 86722252 | HCID 86722252 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86722262 | HCID 86722262 | 61.5% |
Reaction Steps
A mixture of 12G (2 g, 7 mmol), 11D (2.8 g, 14.5 mmol) in THF (20 mL) was cooled to 0° C. To the mixture was added NaOH (2 g). The reaction mixture was reacted at room temperature overnight. TLC monitored the reaction. After reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 16A (2 g, 61% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08969373B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-57a89331ccec49479c9f21fc73896ff6 |
|---|
| Source note | uspto-grants-2015_03 |
|---|
