反应详情

温度

0 °C

A mixture of 12G (2 g, 7 mmol), 11D (2.8 g, 14.5 mmol) in THF (20 mL) was cooled to 0° C. To the mixture was added NaOH (2 g). The reaction mixture was reacted at room temperature overnight. TLC monitored the reaction. After reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 16A (2 g, 61% yield).

1. customThe reaction mixture was reacted at room temperature overnight
2. customthe reaction
3. customAfter reaction
4. filtrationThe precipitated solids were collected by filtration