反应详情

温度

110 °C

A mixture of 1,5-naphthyridin-4-ol acetic acid salt (D-6) (800 mg, 3.0 mmol, 1.0 eq) in phosphoroxychloride (5 mL, 53 mol, 17.6 eq) is stirred at 110° C. for 30 min, cooled to RT and then concentrated in vacuo. The residue is poured into ice-water (50 mL) and neutralized with saturated aqueous NaHCO3 solution to adjust the pH to 8-9 while keeping the temperature below 5° C. The mixture is stirred at RT for 30 min and then extracted with DCM (3×40 mL). The combined organic layers are washed with brine, dried over Na3SO4 and filtered. The filtrate is concentrated in vacuo and the residue is purified by flash column chromatography on silica gel (1-2% MeOH-DCM) to afford the product, 4-chloro-1,5-naphthyridine (D-7).

1. temperaturecooled to RT
2. concentrationconcentrated in vacuo
3. additionThe residue is poured into ice-water (50 mL)
4. customthe temperature below 5° C
5. stirringThe mixture is stirred at RT for 30 min
6. extractionextracted with DCM (3×40 mL)
7. washThe combined organic layers are washed with brine
8. dry with materialdried over Na3SO4
9. filtrationfiltered
10. concentrationThe filtrate is concentrated in vacuo
11. customthe residue is purified by flash column chromatography on silica gel (1-2% MeOH-DCM)