HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86676285, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Reactant | 1-Amino-3,3-diethoxypropane | HCID 521029 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 86676285 | HCID 86676285 | — |
Reaction Steps
The mixture of 2,4-dichloropyrimidine (A-1) (20 g, 134 mmol), 3,3-diethoxypropan-1-amine (19.6 g, 147 mmol) and Et3N (20.5 mL, 147 mmol) in ethanol (250 mL) is stirred at RT for 24 h. The mixture is concentrated in vacuo and the residue is purified by flash column chromatography to afford the 2-chloro-N-(2,2-diethoxyethyl)pyrimidin-4-amine (A-2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969363B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-67a3dc68fd24470294d000d584ba987b |
| Source note | uspto-grants-2015_03 |