Triethylamine → HCID 86676285, compound

HRID 869455Notes

Reaction equation

HRID 869455 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH2:9]([O:11][CH:12]([O:16][CH2:17][CH3:18])[CH2:13]CN)[CH3:10].CC[N:21](CC)CC>C(O)C>[Cl:1][C:2]1[N:7]=[C:6]([NH:21][CH2:13][CH:12]([O:16][CH2:17][CH3:18])[O:11][CH2:9][CH3:10])[CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 775312,4-DichloropyrimidineHCID 5210291-Amino-3,3-diethoxypropane

Product 1

HCID 86676285HCID 86676285, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The mixture of 2,4-dichloropyrimidine (A-1) (20 g, 134 mmol), 3,3-diethoxypropan-1-amine (19.6 g, 147 mmol) and Et3N (20.5 mL, 147 mmol) in ethanol (250 mL) is stirred at RT for 24 h. The mixture is concentrated in vacuo and the residue is purified by flash column chromatography to afford the 2-chloro-N-(2,2-diethoxyethyl)pyrimidin-4-amine (A-2).

Workup

  1. concentrationThe mixture is concentrated in vacuo
  2. customthe residue is purified by flash column chromatography

Sources & evidence

ORD record
ord-67a3dc68fd24470294d000d584ba987b
Source dataset
uspto-grants-2015_03
Patent number
US08969363B2

Reaction notes

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