HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethyl)-1H-benzimidazole → (E)-2-(3-fluoro-8-{[2-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl]methyl}dibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethyl)-1H-benzimidazole | HCID 67560 | — |
| Reactant | (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile | HCID 86721333 | — |
| Product | (E)-2-(3-fluoro-8-{[2-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl]methyl}dibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile | HCID 86721340 | 88.9% |
Reaction Steps
Using 2-(trifluoromethyl)-1H-benzo[d]imidazole (62 mg, 0.335 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (120 mg, 0.335 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (138 mg, 88%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969345B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-59fc9319640f4ac6aa85d424d8b7480a |
| Source note | uspto-grants-2015_03 |