Diethyl Ether → 2-chloro-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidin-4-amine

HRID 86953Notes

Reaction equation

HRID 86953 reaction equation
[CH3:23][CH2:24][O:25][CH2:26][CH3:27].[Cl:1][c:2]1[n:3][c:4]([Cl:11])[c:5]2[c:6]([n:7]1)[cH:8][cH:9][o:10]2.[F:17][C:18]([CH2:19][NH2:20])([F:21])[F:22].[O:12]=[CH:13][N:14]([CH3:15])[CH3:16]>>[Cl:1][c:2]1[n:3][c:4]([NH:20][CH2:19][C:18]([F:17])([F:21])[F:22])[c:5]2[c:6]([n:7]1)[cH:8][cH:9][o:10]2

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 6228DimethylformamideHCID 9773Ethanamine, 2,2,2-trifluoro-HCID 457899682,4-Dichlorofuro[3,2-D]pyrimidine

Product 1

HCID 866651142-chloro-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-979c14d006174759ba4682fb1248f02a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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