HCID 68893980, compound → HCID 86721380, compound

HRID 869547Notes

Reaction equation

HRID 869547 reaction equation
[CH2:1]([C:4]1[NH:12][C:7]2=[N:8][CH:9]=[CH:10][N:11]=[C:6]2[N:5]=1)[CH2:2][CH3:3].Br[CH2:14][C:15]1[CH:34]=[CH:33][C:18]2/[C:19](=[C:29](/[CH3:32])\[C:30]#[N:31])/[C:20]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:21]=3[O:22][CH2:23][C:17]=2[CH:16]=1>>[F:28][C:25]1[CH:26]=[CH:27][C:20]2=[C:21]([CH:24]=1)[O:22][CH2:23][C:17]1[CH:16]=[C:15]([CH2:14][N:12]3[C:7]4=[N:8][CH:9]=[CH:10][N:11]=[C:6]4[N:5]=[C:4]3[CH2:1][CH2:2][CH3:3])[CH:34]=[CH:33][C:18]=1/[C:19]/2=[C:29](/[CH3:32])\[C:30]#[N:31]

Participants

3

Reactant 2

HCID 68893980HCID 68893980, compoundHCID 86721333(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile

Product 1

HCID 86721380HCID 86721380, compoundYield 74%

Procedure

[step 2] Using 2-propyl-1H-imidazo[4,5-b]pyrazine (68 mg, 0.42 mmol) obtained in step 1 and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (153 mg, 0.43 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (136 mg, 74%) was obtained.

Workup

  1. customobtained in Reference Example 1

Sources & evidence

ORD record
ord-90d185bc31df435fa6c6892bd6d8336f
Source dataset
uspto-grants-2015_03
Patent number
US08969345B2

Reaction notes

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