HCID 596076, compound → HCID 86721439, compound

HRID 869588Notes

Reaction equation

HRID 869588 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([CH:8]([CH3:10])[CH3:9])[NH:5][C:6]=1[Cl:7].Br[CH2:12][C:13]1[CH:32]=[CH:31][C:16]2/[C:17](=[C:27](/[CH3:30])\[C:28]#[N:29])/[C:18]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][C:19]=3[O:20][CH2:21][C:15]=2[CH:14]=1>>[Cl:1][C:2]1[N:3]=[C:4]([CH:8]([CH3:10])[CH3:9])[N:5]([CH2:12][C:13]2[CH:32]=[CH:31][C:16]3/[C:17](=[C:27](/[CH3:30])\[C:28]#[N:29])/[C:18]4[CH:25]=[CH:24][C:23]([F:26])=[CH:22][C:19]=4[O:20][CH2:21][C:15]=3[CH:14]=2)[C:6]=1[Cl:7]

Participants

3

Reactant 2

HCID 596076HCID 596076, compoundHCID 86721333(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile

Product 1

HCID 86721439HCID 86721439, compoundYield 91%

Procedure

[step 2] Using 4,5-dichloro-2-isopropyl-1H-imidazole (68 mg, 0.381 mmol) obtained in step 1 and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (130 mg, 0.363 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (150 mg, 91%) was obtained.

Workup

  1. customobtained in Reference Example 1

Sources & evidence

ORD record
ord-7c737d2e2156466e920b7bb11a95bb78
Source dataset
uspto-grants-2015_03
Patent number
US08969345B2

Reaction notes

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