Ethanol → Ethyl 3-hydroxy-5-methoxypicolinate

HRID 869635Notes

Reaction equation

HRID 869635 reaction equation
[OH:1][C:2]1[C:3]([C:10]([OH:12])=[O:11])=[N:4][CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1.[CH2:13](O)[CH3:14]>S(=O)(=O)(O)O.C(OCC)(=O)C>[OH:1][C:2]1[C:3]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[N:4][CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1

Participants

5

Reactant 2

HCID 702EthanolHCID 215430083-Hydroxy-5-methoxypicolinic acid

Product 1

HCID 66962131Ethyl 3-hydroxy-5-methoxypicolinateYield 76%

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 8857Ethyl AcetateSolvent

Procedure

3-hydroxy-5-methoxypicolinic acid (200 mg, 1.18 mmol) was dissolved in ethanol (10 mL). To the mixture was added one drop of sulfuric acid. The mixture was refluxed with stirring for 3 days. After cooling to room temperature, the mixture was concentrated in vacuo to afford an oil. The residual oil was dissolved in ethyl acetate and washed with aq. sodium bicarbonate and brine. The extract was dried over sodium sulfate and concentrated in vacuo to afford an oil. The residual oil was purified by silica gel column chromatography (ethyl acetate/hexane 1:3 to 1:1) to afford 178 mg (76%) of the title compound as a white solid.

Workup

  1. temperatureThe mixture was refluxed
  2. concentrationthe mixture was concentrated in vacuo
  3. customto afford an oil
  4. washwashed with aq. sodium bicarbonate and brine
  5. dry with materialThe extract was dried over sodium sulfate
  6. concentrationconcentrated in vacuo
  7. customto afford an oil
  8. customThe residual oil was purified by silica gel column chromatography (ethyl acetate/hexane 1:3 to 1:1)

Sources & evidence

ORD record
ord-f85fc349153d4aadaf47d4061d5f92e1
Source dataset
uspto-grants-2015_03
Patent number
US08969383B2

Reaction notes

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