Indole-2-carboxylic acid → HCID 178431203, compound

HRID 869665Notes

Reaction equation

HRID 869665 reaction equation
Cl.Cl.[Cl:3][C:4]1[CH:5]=[C:6]([O:12][CH2:13][C:14]2([CH3:19])[CH2:18][CH2:17][NH:16][CH2:15]2)[C:7]([C:10]#[N:11])=[N:8][CH:9]=1.[F:20][C:21]([F:32])([F:31])[C@H:22]1[CH2:27][CH2:26][C@H:25]([C:28](O)=[O:29])[CH2:24][CH2:23]1.N1C2C(=CC=CC=2)C=C1C(O)=O>>[Cl:3][C:4]1[CH:5]=[C:6]([O:12][CH2:13][C:14]2([CH3:19])[CH2:18][CH2:17][N:16]([C:28]([C@H:25]3[CH2:24][CH2:23][C@H:22]([C:21]([F:20])([F:31])[F:32])[CH2:27][CH2:26]3)=[O:29])[CH2:15]2)[C:7]([C:10]#[N:11])=[N:8][CH:9]=1

Participants

4

Reactant 3

HCID 72899Indole-2-carboxylic acidHCID 66961881HCID 66961881, compoundHCID 178525710HCID 178525710, compound

Product 1

HCID 178431203HCID 178431203, compound

Procedure

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 1 using 5-chloro-3-((3-methylpyrrolidin-3-yl)methoxy)picolinonitrile dihydrochloride (EXAMPLE 84, Step 4) and trans-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride and indole-2-carboxylic acid.

Sources & evidence

ORD record
ord-5141ec599d3f49acbd4451237e0d22c6
Source dataset
uspto-grants-2015_03
Patent number
US08969383B2

Reaction notes

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