反应详情

A suspension of ethyl 5-[3-(benzyloxy)propyl]-6-hydroxy-3-methylpyrazine-2-carboxylate (2.91 g, 8.80 mmol) and palladium hydroxide (1.06 g) in ethanol (60 mL) was refluxed for 7 h. After being cooled to ambient temperature, the reaction mixture was filtrated through celite with ethanol. The filtrate was combined and concentrated in vacuo. The crude was purified by silica gel column chromatography (chloroform to chloroform:methanol=19:1) to give ethyl 6-hydroxy-5-(3-hydroxypropyl)-3-methylpyrazine-2-carboxylate. MS (APCI): m/z 241 (M+H).

1. temperaturewas refluxed for 7 h
2. filtrationthe reaction mixture was filtrated through celite with ethanol
3. concentrationconcentrated in vacuo
4. customThe crude was purified by silica gel column chromatography (chloroform to chloroform:methanol=19:1)