HRID8700

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

HCID566537

1-Piperidinepentanol

C10H21NO

HCID15870142

未命名化合物

PRODUCTS

生成物

结构：Cc1nc(OCCCCCN2CCCCC2)cc(-c2ccc(F)cc2)n1

HCID6433114

4-(4-Fluorophenyl)-2-methyl-6-{[5-(piperidin-1-yl)pentyl]oxy}pyrimidine

C21H28FN3O

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8078

Cyclohexane

C6H12

PROCEDURE

实验过程

13.8 kg of 4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine, 4.8 kg of 60% sodium hydride, 130 kg of cyclohexane and 10.6 kg of 5-piperidino-1-pentanol were stirred under reflux for 4 hours.

WORKUP

后处理

temperatureunder reflux for 4 hours