反应详情

To a suspension of 4-{(1S)-1-[(tert-butoxycarbonyl)amino]ethyl}benzoic acid from Example 1, Step 8 (48.0 g, 181 mmol) in MeOH (175 mL) at r.t. was added chlorotrimethylsilane (116 mL, 905 mmol) and the suspension was stirred at r.t. for 6 h (became a clear solution). The solution was concentrated in vacuo to give a white solid which was triturated with ether and filtered. The white solid was collected and dried under high vacuum to give the desired product.

1. concentrationThe solution was concentrated in vacuo
2. customto give a white solid which
3. customwas triturated with ether
4. filtrationfiltered
5. customThe white solid was collected
6. customdried under high vacuum