Chlorotrimethylsilane → [(1S)-1-(4-methoxycarbonylphenyl)ethyl]azanium chloride

Participants

Reaction Steps

To a suspension of 4-{(1S)-1-[(tert-butoxycarbonyl)amino]ethyl}benzoic acid from Example 1, Step 8 (48.0 g, 181 mmol) in MeOH (175 mL) at r.t. was added chlorotrimethylsilane (116 mL, 905 mmol) and the suspension was stirred at r.t. for 6 h (became a clear solution). The solution was concentrated in vacuo to give a white solid which was triturated with ether and filtered. The white solid was collected and dried under high vacuum to give the desired product.

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