HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl 4-[(1S)-1-({[5-bromo-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate → 4-[(1S)-1-({[5-bromo-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl 4-[(1S)-1-({[5-bromo-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate | HCID 57900972 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | 4-[(1S)-1-({[5-bromo-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoic acid | HCID 24952578 | — |
Reaction Steps
Methyl 4-[(S)-1-({[5-bromo-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate from Example 4, Step 1 (25.0 mg, 0.0507 mmol) was reacted under conditions similar to Example 1, Step 11. After trituration of the crude product in 1:1 EtOAc/hexane, the desired product was obtained as an off-white solid. MS (−APCI): m/z 476 (M−1)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969394B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-5bb0397b380245f28e9335c5252bb57a |
| Source note | uspto-grants-2015_03 |