HCID 57900985, compound → HCID 24178408, compound

HRID 870045Notes

Reaction equation

HRID 870045 reaction equation
[Br:1][C:2]1[S:3][C:4]([Br:30])=[C:5]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=2)[C:6]=1[C:7]([NH:9][C@H:10]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18]C)=[O:17])=[CH:14][CH:13]=1)[CH3:11])=[O:8]>CCOC(C)=O.CCCCCC>[Br:1][C:2]1[S:3][C:4]([Br:30])=[C:5]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=2)[C:6]=1[C:7]([NH:9][C@H:10]([C:12]1[CH:13]=[CH:14][C:15]([C:16]([OH:18])=[O:17])=[CH:20][CH:21]=1)[CH3:11])=[O:8]

Participants

3

Reactant 1

HCID 57900985HCID 57900985, compound

Product 1

HCID 24178408HCID 24178408, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Methyl 4-[(1S)-1-({[2,5-dibromo-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate from Example 5, Step 1 (27.0 mg, 0.0472 mmol) was reacted under conditions similar to Example 1, Step 11. After trituration of the crude product in 1:9 EtOAc/hexane, the desired product was obtained as a white solid. MS (−APCI): m/z 554 (M−1)−.

Sources & evidence

ORD record
ord-71576893a6bc41558b50280eb569dc78
Source dataset
uspto-grants-2015_03
Patent number
US08969394B2

Reaction notes

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