Benzyl Bromide → Diethyl 4-(benzyloxy)pyridine-2,6-dicarboxylate

Participants

Reaction Conditions

Reaction Steps

To a solution of 4 (6.88 g, 28 mmol) in acetonitrile and K2CO3 (6.31 g, 45 mmol) was carefully added benzyl bromide (3.34 mL, 27 mmol). The resulting solution was stirred at 82° C. under reflux overnight. The reaction was stopped by filtration of K2CO3 and the solvent was removed under reduced pressure. The solid obtained was recrystallized from hot hexanes to yield 96% of the product as a white solid.

Provenance & Evidence