Trifluoroacetic acid → HCID 86626025, compound

HRID 870386Notes

Reaction equation

HRID 870386 reaction equation
C(OC([N:8]([CH2:27][CH2:28][CH3:29])[CH:9]1[CH2:18][C:17]2[C:12](=[CH:13][C:14]([O:19][S:20]([C:23]([F:26])([F:25])[F:24])(=[O:22])=[O:21])=[CH:15][CH:16]=2)[O:11][CH2:10]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH2:27]([NH:8][CH:9]1[CH2:18][C:17]2[C:12](=[CH:13][C:14]([O:19][S:20]([C:23]([F:25])([F:26])[F:24])(=[O:22])=[O:21])=[CH:15][CH:16]=2)[O:11][CH2:10]1)[CH2:28][CH3:29]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86626024HCID 86626024, compound

Product 1

HCID 86626025HCID 86626025, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoro-methanesulfonic acid 3-(tert-butoxycarbonyl-propyl-amino)-chroman-7-yl ester (2.1 g, 4.78 mmol) was dissolved in dichloromethane (30 ml). Trifluoroacetic acid (3 ml) was added and the reaction mixture was stirred at room temperature for 3 hours. The reaction mixture was evaporated to dryness. Dichloromethane was added (twice) and the reaction mixture was evaporated to dryness to give the product (2.6 g, 65% purity).

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. additionDichloromethane was added (twice) and the reaction mixture
  3. customwas evaporated to dryness
  4. customto give the product (2.6 g, 65% purity)

Sources & evidence

ORD record
ord-8336351f88394653b8907b41f7ef1dd2
Source dataset
uspto-grants-2015_03
Patent number
US08969552B2

Reaction notes

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