反应详情

温度

35 °C

To a suspension of N-(4-((2-aminopyridin-4-yl)oxy)-2,3-difluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (135 mg, 0.3 mmol) in acetic anhydride (6 mL) was added Et3N (0.4 mL, 2.9 mmol). The reaction mixture was stirred at 35° C. for 4 hours, then filtered, and the filter cake washed with PE (5 mL), EtOAc (5 mL) and CH3OH (2 mL) respectively to give the title compound as a beige solid (102 mg, 68.9%).

1. filtrationfiltered
2. washthe filter cake washed with PE (5 mL), EtOAc (5 mL) and CH3OH (2 mL) respectively