反应详情

To a solution of N-(4-((2-aminopyridin-4-yl)oxy)-2,5-difluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (220 mg, 0.48 mmol) in (Ac)2O (8 mL) was added Et3N (0.5 mL, 1.32 mmol). The reaction mixture was stirred at rt for 8 hours and concentrated in vacuo. The residue was purified by a silica gel column chromatography (DCM/CH3OH (v/v)=10/1) to give the title compound as a white solid (175 mg, 73%).

1. concentrationconcentrated in vacuo
2. customThe residue was purified by a silica gel column chromatography (DCM/CH3OH (v/v)=10/1)