反应详情

5.0 g 3-Fluoro-4-hydroxy-benzonitrile, 7.3 mL isopropyl iodide and 6.05 g potassium carbonate were placed in 54 mL acetone and heated to reflux where the reaction was maintained for 24 h. After this time, the mixture was cooled to ambient temperature and concentrated under reduced pressure. The material that remained was partitioned between ethyl acetate and water and the aqueous phase was removed and extracted with additional ethyl acetate. The combined organics were dried, filtered and the solvent was removed from the filtrate under reduced pressure to give the title compound that was used without further purification.

1. temperatureheated
2. temperatureto reflux where the reaction
3. temperaturewas maintained for 24 h
4. concentrationconcentrated under reduced pressure
5. customThe material that remained was partitioned between ethyl acetate and water
6. customthe aqueous phase was removed
7. extractionextracted with additional ethyl acetate
8. customThe combined organics were dried
9. filtrationfiltered
10. customthe solvent was removed from the filtrate under reduced pressure