Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 58072031 | HCID 58072031 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 66713639 | HCID 66713639 | — |
Reaction Steps
110 mg (4R)-4-(1-hydroxy-3-methoxypropyl)-1-((R)-1-phenylethyl)pyrrolidine-2-one (I.17) was dissolved in 5 mL trifluoroacetic acid and stirred at 150° C. in the microwave for 45 min. Water was added and the mixture was concentrated at 60° C. Co-evaporation with toluene and dichloromethane provided the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08969568B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-529608ce34554dc092805bc964f37673 |
|---|
| Source note | uspto-grants-2015_03 |
|---|
