Water → HCID 66713639, compound

HRID 870525Notes

Reaction equation

HRID 870525 reaction equation
[OH:1][CH:2]([C@H:7]1[CH2:11][N:10]([C@@H](C2C=CC=CC=2)C)[C:9](=[O:20])[CH2:8]1)[CH2:3][CH2:4][O:5][CH3:6].O>FC(F)(F)C(O)=O>[OH:1][C@@H:2]([C@H:7]1[CH2:11][NH:10][C:9](=[O:20])[CH2:8]1)[CH2:3][CH2:4][O:5][CH3:6]

Participants

4

Reactant 2

HCID 962WaterHCID 58072031HCID 58072031, compound

Product 1

HCID 66713639HCID 66713639, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
150 °C

Procedure

110 mg (4R)-4-(1-hydroxy-3-methoxypropyl)-1-((R)-1-phenylethyl)pyrrolidine-2-one (I.17) was dissolved in 5 mL trifluoroacetic acid and stirred at 150° C. in the microwave for 45 min. Water was added and the mixture was concentrated at 60° C. Co-evaporation with toluene and dichloromethane provided the title compound.

Workup

  1. concentrationthe mixture was concentrated at 60° C
  2. customCo-evaporation with toluene and dichloromethane

Sources & evidence

ORD record
ord-529608ce34554dc092805bc964f37673
Source dataset
uspto-grants-2015_03
Patent number
US08969568B2

Reaction notes

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