Trifluoroacetic acid → HCID 58071883, compound

HRID 870526Notes

Reaction equation

HRID 870526 reaction equation
[NH2:1][C@H:2]([C@H:4]1[CH2:8][N:7]([C@H](C2C=CC=CC=2)C)[C:6](=[O:17])[CH2:5]1)C.F[C:19](F)(F)C(O)=O>>[NH2:1][CH2:2][C@@H:4]1[C@@H:8]([CH3:19])[NH:7][C:6](=[O:17])[CH2:5]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11776125HCID 11776125, compound

Product 1

HCID 58071883HCID 58071883, compound

Conditions

Temperature
150 °C

Procedure

20 mg (R)-4-((S)-1-aminoethyl)-1-((S)-1-phenylethyl)pyrrolidine-2-one (I.22) was dissolved in trifluoroacetic acid and stirred for 90 min in the microwave at 150° C. The mixture was concentrated and used without further purification.

Workup

  1. concentrationThe mixture was concentrated
  2. customused without further purification

Sources & evidence

ORD record
ord-c9a1e032686c49a48d084f94f83fa7ee
Source dataset
uspto-grants-2015_03
Patent number
US08969568B2

Reaction notes

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