HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 58072023, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | HCID 58072000 | HCID 58072000 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58072023 | HCID 58072023 | — |
Reaction Steps
400 mg Trifluoromethanesulfonic acid 7-(6-morpholine-4-yl-pyridine-3-yl)-[1,6]-naphthyridine-5-yl ester (6.5) in 5 mL N-methyl-2-pyrrolidinone was treated with 1.6 mL (4N) hydrochloric acid in dioxane for 30 min at 70° C. 2 mL dichloromethane, 20 mL ethyl acetate and 10 mL methyl-tert-butylether was added and the precipitate isolated and dried at 50° C. under vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969568B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-55689509d2a340d9a712a8002d5122d1 |
| Source note | uspto-grants-2015_03 |