Hydrochloric Acid → HCID 58072023, compound

HRID 870535Notes

Reaction equation

HRID 870535 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][C:10]([C:13]3[CH:22]=[C:21]4[C:16]([CH:17]=[CH:18][CH:19]=[N:20]4)=[C:15](OS(C(F)(F)F)(=O)=O)[N:14]=3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl.[Cl:32]CCl.C(OCC)(=O)C>CN1CCCC1=O.O1CCOCC1.COC(C)(C)C>[Cl:32][C:15]1[N:14]=[C:13]([C:10]2[CH:11]=[N:12][C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[CH:8][CH:9]=2)[CH:22]=[C:21]2[C:16]=1[CH:17]=[CH:18][CH:19]=[N:20]2

Participants

8

Reactant 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 58072000HCID 58072000, compound

Product 1

HCID 58072023HCID 58072023, compound

Reagents, catalysts & solvents 3

HCID 13387N-methyl-2-pyrrolidoneSolventHCID 15413tert-Butyl methyl etherSolventHCID 312751,4-DioxaneSolvent

Procedure

400 mg Trifluoromethanesulfonic acid 7-(6-morpholine-4-yl-pyridine-3-yl)-[1,6]-naphthyridine-5-yl ester (6.5) in 5 mL N-methyl-2-pyrrolidinone was treated with 1.6 mL (4N) hydrochloric acid in dioxane for 30 min at 70° C. 2 mL dichloromethane, 20 mL ethyl acetate and 10 mL methyl-tert-butylether was added and the precipitate isolated and dried at 50° C. under vacuo.

Workup

  1. customthe precipitate isolated
  2. customdried at 50° C. under vacuo

Sources & evidence

ORD record
ord-55689509d2a340d9a712a8002d5122d1
Source dataset
uspto-grants-2015_03
Patent number
US08969568B2

Reaction notes

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