HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 870540Generated: October 30, 2026
Trifluoroacetic acid → HCID 58071909, compound
https://huagongshe.com/reaction/870540
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 58071883 | HCID 58071883 | — |
| Reactant | HCID 58071952 | HCID 58071952 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 58071909 | HCID 58071909 | — |
Reaction Steps
100 mg 6.1 and 33 mg (4R,5R)-4-(aminomethyl)-5-methylpyrrolidine-2-one (2.26) were dissolved in dimethylacetamide. 0.175 mL Diisopropylethylamine was added and the mixture was heated at 80° C. for 85 min. The mixture was acidified with trifluoroacetic acid and purified via chromatography (RP-HPLC) and the corresponding fractions were freeze-dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08969568B2 |
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| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-9105618b456348ecb3bd2a249de5c8a6 |
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| Source note | uspto-grants-2015_03 |
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