Trifluoroacetic acid → HCID 58071909, compound

HRID 870540Notes

Reaction equation

HRID 870540 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:22]=[C:21]3[C:16]([CH:17]=[CH:18][CH:19]=[N:20]3)=[C:15](OS(C(F)(F)F)(=O)=O)[N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[NH2:31][CH2:32][C@@H:33]1[C@@H:37]([CH3:38])[NH:36][C:35](=[O:39])[CH2:34]1.C(N(C(C)C)CC)(C)C.FC(F)(F)C(O)=O>CC(N(C)C)=O>[CH3:38][C@H:37]1[NH:36][C:35](=[O:39])[CH2:34][C@@H:33]1[CH2:32][NH:31][C:15]1[N:14]=[C:13]([C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=2)[CH:22]=[C:21]2[C:16]=1[CH:17]=[CH:18][CH:19]=[N:20]2

Participants

6

Reactant 4

HCID 6422Trifluoroacetic acidHCID 81531DiisopropylethylamineHCID 58071883HCID 58071883, compoundHCID 58071952HCID 58071952, compound

Product 1

HCID 58071909HCID 58071909, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Conditions

Temperature
80 °C

Procedure

100 mg 6.1 and 33 mg (4R,5R)-4-(aminomethyl)-5-methylpyrrolidine-2-one (2.26) were dissolved in dimethylacetamide. 0.175 mL Diisopropylethylamine was added and the mixture was heated at 80° C. for 85 min. The mixture was acidified with trifluoroacetic acid and purified via chromatography (RP-HPLC) and the corresponding fractions were freeze-dried.

Workup

  1. custompurified via chromatography (RP-HPLC)
  2. customthe corresponding fractions were freeze-dried

Sources & evidence

ORD record
ord-9105618b456348ecb3bd2a249de5c8a6
Source dataset
uspto-grants-2015_03
Patent number
US08969568B2

Reaction notes

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