HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 870616Generated: November 2, 2026
Hydrochloric Acid → 4-(2H-triazol-4-yloxy)butanoic acid
https://huagongshe.com/reaction/870616
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | methyl 4-(2H-triazol-4-yloxy)butanoate | HCID 86726579 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(2H-triazol-4-yloxy)butanoic acid | HCID 86726581 | 100.7% |
Reaction Steps
Add 1N sodium hydroxide (2.32 mL; 2.0 equiv; 2.32 mmoles) to a solution of methyl 4-(2H-triazol-4-yloxy)butanoate (0.215 g; 1.0 equiv; 1.16 mmoles) in ethanol (1 mL) and heat the mixture to 60° C. for 16 hours. Add 1N hydrochloric acid (2.32 mL; 2.0 equiv; 2.32 mmoles) and concentrate to afford 4-(2H-triazol-4-yloxy)butanoic acid (0.20 g; 100%). Use without further purification in the next step: MS (m/z): 170(M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08969555B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-22cbbcf9c8a9473da21557204933a111 |
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| Source note | uspto-grants-2015_03 |
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