反应详情

温度

60 °C

Add 1N sodium hydroxide (2.32 mL; 2.0 equiv; 2.32 mmoles) to a solution of methyl 4-(2H-triazol-4-yloxy)butanoate (0.215 g; 1.0 equiv; 1.16 mmoles) in ethanol (1 mL) and heat the mixture to 60° C. for 16 hours. Add 1N hydrochloric acid (2.32 mL; 2.0 equiv; 2.32 mmoles) and concentrate to afford 4-(2H-triazol-4-yloxy)butanoic acid (0.20 g; 100%). Use without further purification in the next step: MS (m/z): 170(M−1).

1. concentrationconcentrate